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But one important systemic effect often overlooked is: Hypokalemia Mechanism: receptor stimulation cAMP Activates Na/K-ATPase pump Drives potassium into cells Result: Decreased serum potassium levels (hypokalemia) Clinical significance: Risk of cardiac arrhythmias Muscle weakness More pronounced with: High doses (e.g., nebulization) Concurrent use of diuretics Interesting point: This effect is sometimes therapeutically used in managing hyperkalemia